Furthermore, its antibacterial activity was much better than antifungal activity. Pdf an invitro evaluation of antibacterial activity of. The major disadvantage of curcumin as a therapeutic agent is its low aqueous solubility and poor bioavailability. The oil was extracted from the mother liquor using hexane at 60 degrees c, and the hexane extract was separated into three fractions using silica gel column chromatography. Antibacterial activity was tested by agar well diffusion method mukherjee et al. The antibacterial activities of curcumin were first reported by e. Curcumin is well known as a natural and green food additive, and has effective biological and pharmaceutical activity. Additionally, fabrication of silver nanocomposite lms impregnated with curcumin showed the stronger antibacterial activity against e. In this study, the antimicrobial effect of curcumin. Jecfa specifications define only curcumin extracted from natural source materials. This study investigated the susceptibility of enterotoxigenic escherichia coli to curcumin, as well as its synergistic effect with 12 antimicrobial drugs. The results indicate that turmeric essential oil is an extremely strong antioxidant and antimicrobial antifungal agent with potential application in the food and pharmaceutical industries as a safer alternative to the synthetic antioxidants and antimicrobial agents. These e ects were most dramatic with 330 gml of cur, and the highest fold increases were observed for ceftazidime 74. Drug susceptibility testing and synergistic antibacterial.
Antibacterial activity of curcumin in combination with. Curcumin, a dietary polyphenolic compound, has been shown to have a potent antibacterial activity against a number of pathogenic bacteria including staphylococcus aureus, staphylococcus. Curcumin protects isoproterenol induced my ocar dial infarction in rats21. Curcuma longa, total curcuminoids, curcumin, bisdemethoxycurcumin, demethoxycurcumin, antibacterial activity, antifungal activity. Jul 18, 2011 antibacterial and antifungal properties of turmeric published by neha tandon sinha on july 18, 2011 july 18, 2011 editors note. The antibacterial activity of curcumin against 65 clinical isolates of h. In this research, the ability of curcumin dyed onto cotton fabrics to inhibit the growth of.
Kanamycin was used as standard drug for antibacterial activity and fluconazole as standard for antifungal activity. Antimicrobial activity of curcumin against helicobacter. This is the in vivo first report of antibacterial activity of cobalt curcumin complex against all the bacterial strains tested except escherichia coli. Evaluation of antimicrobial activity of curcuminoids.
Curcumin, cobalt curcumin complex, antibacterial activity address for correspondence email. The rhizome extract of curcuma longa showed significant activity against all tested bacteria and showd. Antimicrobial activity of curcuminoids from curcuma longa l. Antimicrobial activity of curcuminloaded myristic acid. Agar well diffusion method discussion in essence, endodontic infection is the infection of dental root. Activity of curcumin soheilzorofchianmoghadamtousi,1 habsahabdulkadir,1 pouyahassandarvish,2 hassantajik,3 sazalyabubakar,2 andkeivanzandi2,4. The oil showed the best antimicrobial activity against candida albicans. The most studied activity of the curcumin in the past 10 years is the anticancer effects. The mechanism of antibacterial action of curcumin nanoparticles was investigated by transmission electron micrograph tem analysis, which revealed that these particles entered inside the bacterial cell by completely breaking the cell wall, leading to cell death. However, the effects of crosslinking on the release of. Our study shows that curcumin did not affect bacterial growth. Curcumin possesses antibacterial activity against periodontopathic bacteria, and may be a potent agent for preventing periodontal diseases. Pdf antibacterial activity of indium curcumin and indium.
Antibacterial activity of curcuma longa varieties against different strains of bacteria shagufta naz1, safia jabeen1, saiqa ilyas1 farkhanda manzoor2, farah aslam1 and aamir ali3 1department of botany, lahore college for women university, lahore, pakistan 2department of zoology, lahore college for women university. Among all former studies on antibacterial activity of curcumin the most promising result is against helicobacter pylori, at least for using the curcumin as a complementary compound in combination with other existing medicines to decrease the symptoms of gastritis. Because of the extended antimicrobial activity of curcumin and safety property even at high doses 12 gday assessed by clinical trials in human, it was used as a structural sample to design the new antimicrobial agents with modified and increased antimicrobial activities through the synthesis of various derivatives related to curcumin 8, 9. Antibacterial action of curcumin against staphylococcus. These fractions showed antibacterial activity against b. Although previous studies have investigated the effects of curcumin on microorganisms, available knowledge on the effects of curcumin on periodontopathic bacteria is still limited. The oil was extracted from the mother liquor using hexane at 60 c, and the hexane extract was separated into three fractions using silica gel column chromatography.
Phytochemical screening and antimicrobial activity of. Biological activities of curcumin and its analogues. The mode of antimicrobial action of curcumin depends on. Roy, probing the binding site of curcumin in escherichia coli and bacillus subtilis ftsza structural insight to unveil antibacterial activity of curcumin, european journal of medicinal chemistry, vol. Thus, a varied range of natural products of plant, fungi and lichen origin were tested against two bacterial species, staphylococcus aureus atcc 25923 and escherichia coli atcc 25922, by two variants of the agar diffusion. Curcumin is a polyphenol extracted from root of turmeric and known to possess multifunctional properties, including antibacterial activity. Introduction now a days multiple drug resistance has developed due to the indiscriminate use of commercial antimicrobial. Safe, green and efficient antibiotics are urgently needed. Antimicrobial activities for curcumin and rhizome extract of c. Zingiberaceae family and its polyphenolic compound curcumin have been subjected to a variety of antimicrobial investigations due to extensive traditional uses and low side effects. Synergistic antibacterial activity of curcumin with antibiotics against staphylococcus aureus article pdf available in pakistan journal of pharmaceutical sciences 286.
The emergence of multidrugresistant strains further calls for alternative drugs against typhoid. Antimicrobial activity of turmeric extract and its potential. Turmeric compounds can also block mdr1, a gene responsible for resistance to multiple antimicrobial drugs. Antibacterial activity of curcumin against lebanese clinical. Antibacterial and antifungal properties of turmeric nhsjs. Analogues and derivatives curcumin is a member of the linear diarylheptanoid class of. Studies on curcumin, the principal element of turmeric powder, have demonstrated several biological actions such as antibacterial activity. The compounds 4 j, 4 k, and 4 l have exhibited very good activity on methicillin. Enhanced antibacterial activity of curcumin by combination. Curcumin showed the lowest mean of zone of inhibition at both the concentrations indicating minimum antibacterial property. The cobalt curcumin complex could be a suitable candidate for further investigations. No 47 a2, bauxite road, belgaum 590010, karnataka state, india.
Curcumin has a property of antibacterial activity against periodontopathic. Curcumin is the subject of more than 100 clinical trials due to its versatile properties, including antitumor, antiinflammatory, and antioxidant properties. Animal experiments have demonstrated that curcumin applied at high doses has strong antibacterial activity. The role of natural bioactive substances in treating infections has been rediscovered as bacterial resistance become common to most of the antibiotics.
Because of the extended antimicrobial activity of curcumin and safety property even at high doses gday assessed by clinical trials in human. Curcumin is known to exhibit antimicrobial activity against a wide range of bacterial species. Antimicrobial activity of cotton fabrics treated with curcumin. Curcumin, diferuloylmethane from turmeric, has recently been shown to arrest h. Antibacterial study of curcumin loaded electrospun polymers has shown promising results in recent years and makes curcumin an excellent choice as an antibacterial drug 24,31,32. Antibacterial and antioxidant activity evaluation of novel. Curcumin, the yellow color pigment of turmeric, is produced industrially from turmeric oleoresin. A study of antimicrobial activity of few medicinal herbs. The antimicrobial activity of these natural ingredients was better in peroxide treated cotton, formic acid treated woolrabbit hair fibrous substrates than their corresponding intact ones.
In vitro data revealed antimicrobial activity of curcumin against both, mrsa and methicillinsensitive s. Evaluation of antimicrobial activity of curcuminoids isolated. Synthesis and antibacterial activity of cobaltii complex of. Two reference, one clinical and ten environmental strains of staphylococcus aureus s. However, the first paper describing the biological action of curcumin was its antibacterial activity against various bacteria. Antimicrobial activity of curcuminoids from curcuma longa. Certain herbal agents have been reported to have antibacterial activity against h. In vitro curcumin delivery and antibacterial activity of. Grampositive bacteria show a significantly higher sensitivity to curcumin than the gramnegative ones. The methanolic extract of leaf of the plant azadiracta indica, acacia nilotica and witania somnifera showed significant antibacterial activity against bacillus subtilis, escherchia coli, stphaylocuccus aureus and pseudomonas.
The antimicrobial susceptibility of curcumin and antibiotic synergy were identified using disc diffusion on muellerhinton agar. The isolated curcuminoids were identified and characterized by melting point, thin layer chromatography, infra red spectroscopy, nuclear magnetic resonance and mass spectrometry. Aloevera, chitosan, and curcumin were applied in alone and in combination with each others on cotton, wool and rabbit hair by exhaustion method for the assessment of their antimicrobial activity. Biological actions and medicinal applic ations ishita chattopadhyay 1, kaushik biswas 1, uday bandyo p adhyay 2 and ranajit k. Silverdecorated polymeric micelles combined with curcumin. Pdf antibacterial activity of aloe vera, curcumin, garlic. An invitro evaluation of antibacterial activity of curcumin against common endodontic bacteria. This strategy could prevent aggregation of silver nanoparticles and improve the water solubility of curcumin at the same time, which showed enhanced antibacterial activity toward gramnegative p. In vitro curcumin delivery and antibacterial activity of rus 2 and ruo 2 nanoparticles loaded. The test organisms were seeded into respective medium by gently. Antibacterial activity of cubosomal gel containing curcumin a sterile borer was used to prepare cups of 10 mm diameter in the agar media spread with the microorganisms. Cur at 110, 220, or 330 gml enhanced the antibacterial activity of the majority of the tested antibiotics table3. Curcumin has long been known to have an antibacterial activity.
Synergistic e ect of curcumin the possible synergistic e ect of cur was evaluated. The antimicrobial activity of methanol and chloroform extracts was similar to those reported by mohammad et al. Cs in presens and absence of rosemary extracts against the gram negative bacteria pseudomonas aeruginosa pao 1 was evaluated by detection of minimal inhibition concentration mic and minimal bactericidal concentration mbc. This study revealed antibacterial effects of curcumin against standard bacterial strains in high concentrations. Pdf synergistic antibacterial activity of curcumin with. Salmonella is a causative agent of salmonellosis, one of the major reasons for morbidity and mortality throughout the world.
However, its anticancer activities are the most widely studied. The stability and assembly of ftsz protofilaments as a crucial factor for bacterial cytokinesis are introduced as a possible drug target for antibacterial agents. Mullick road, kolkat a 700 032, india 2deptartment of biochemistry, central drug research. It was found that most plant extracts studied had antibacterial and antifungal activities. Antibacterial activity of curcuma longa varieties against. To overcome its hydrophobic disadvantage, here, tannic acid and metal coordination were used to coat curcumin nanoparticles nps for the antibacterial application. Curcumin, fhm and bhm also have anticoagulant activity22,23.
Antibacterial activity of curcumin turmeric against. Recent evidence suggests that ftsz may be considered as an important antibacterial drug target. It can also be produced by chemical synthesis but synthetic curcumin is not used as a food additive stankovic 2014. The successful treatment of typhoid patients is a challenge, especially in immunocompromised individuals. Evaluation of new analogs or new compounds of curcumin for their antibacterial effect is interesting for. Release of curcumin from electrospun polymer matrix has also been studied in several studies 28,31,33,34.
Controlled release of curcumin from electrospun fiber mats. The extensive antiviral effects of curcumin against different viral pathogens nominate this compound as an antiviral drug candidate to develop new antivirals from natural resources against sensitive viruses especially by developing. Synthesis and antibacterial activity of cobaltii complex. Turmeric has antibacterial, antiviral, and antimicrobial properties that could make it a natural herbal alternative to fight off these infections. Curcumin exhibited significant antibacterial activity with minimum inhibitory concentration mic values between 5 and 50. Jan 29, 2008 the assembly and stability of ftsz protofilaments have been shown to play critical roles in bacterial cytokinesis. Though the nhsjs usually features work by high schoolers, it occasionally gets the chance to showcase extraordinary research done by young scientists across the country. Banerjee 1, 1department of physiology, indian institute of chemical biology, 4, raja s. The main objective of this study was to evaluate the antibacterial activity of curcumin in combination with tetracycline or ciprofloxacin against staphylococcus aureus s.
Helicobacter pylori is a bacterium implicated in the etiology of gastritis and peptic ulcers. Antibacterial activity of curcumin against periodontopathic bacteria article pdf available in journal of periodontology 871. This study evaluated the synergistic antibacterial activity of curcumin with 8 different antibiotic groups. Antibacterial synergy of curcumin with antibiotics against. All the three isolated curcuminoids were evaluated for antibacterial activity by agar diffusion. Apr 29, 2014 these results demonstrated promising antibacterial activity for different curcumin derivatives as well. It was shown that the bactericidal activity of sodium carboxymethyl cellulose silver nanocomposite lms scmc. Antibacterial synergy of curcumin with antibiotics against biofilm producing clinical bacterial isolates abstract introduction. Study of antimicrobial activity of aloevera, chitosan, and. Dec 30, 2019 in the testing of antibacterial activity, the synthesized analogs displayed variable activities with a superior effect attributed to chloridebased analogs. Antibacterial activity of curcumin against periodontopathic. Between group comparison of antibacterial activity of various agents against enterococcus faecalis. The mother liquor after isolation of curcumin from oleoresin contains approximately 40% oil. Curcumin finished wool had semidurable antimicrobial activity, less durable to light exposure than home.
In the course of performing these tests, it could be deduced that both stability and solubility of the analogs were improved in comparison with curcumin. Zones of inhibition produced by turmeric extracts in the present study were about 10. The antibacterial activity of the test solution curcumin biopurify phytochemicals ltd. There is a need for further in vivo studies to shed light on antibacterial effects of curcumin with high concentrations. The compounds 4 d, 4 j, 4 l, have shown better antibacterial activity than ciprofloxacin and parent curcumin in both gram. In this work, we design a novel polymeric micelle for simultaneous decorating of silver nanoparticles and encapsulating of curcumin as a combination strategy to improve the antibacterial efficiency. In vitro curcumin delivery and antibacterial activity of rus2. The absolute purity of curcumin 100% was assessed by. Review article antibacterial action of curcumin against. Different concentrations of the turmeric curcuminoids and oil were prepared in ethanol and methanol respectively by using serial dilution method. View the article pdf and any associated supplements and figures for a period of 48 hours. However, curcumin and cotton have low affinity and therefore the ability of curcumin to impart durable antimicrobial activity on cotton needs to be studied.