Use of a highsensitivity assay prompted reclassification of 1771 17% of 10 360 patients with myocardial injury or infarction, but was not associated with a lower subsequent incidence of myocardial infarction or cardiovascular death at 1 year. Pe or further investigations within the community e. Ruling out ami based on a single hsctn determination. Troponin assays with varying sensitivities are available. Troponin i and t are specific to cardiac muscles, unlike troponin c which is associated with.
Diagnostic performance of high sensitivity troponin in non. Rev esp cardiol 2012 ytroponin elevation in heart failure. Recommendations for the use of cardiac troponin measurement in acute. Our findings question whether the diagnostic threshold for myocardial infarction should be based on the 99th centile derived from a normal reference. Highsensitivity troponin in the evaluation of patients. For detailed information on assay file installation and on viewing and editing assay parameters, refer to the architect system operations manual. The architect stat troponini assay file must be installed on the architect i system with stat protocol capability from the architect i assay cdrom addition b prior to performing the assay.
Jaffe and others published troponina cardiaca ultrasensible. Troponin levels marginally above 30 ngl do occur with alternative pathology. To assess the diagnostic performance of highsensitivity troponin t hstnt in patients with suspected nonst elevation acute coronary syndrome nsteacs. Sensitive or contemporary assays have been in use for a number of years. Investigations show that when hsctn is undetectable, ami is unlikely.
Troponin t tnt is a component of the contractile apparatus of the striated musculature. Highsensitivity cardiac troponin in the evaluation of. Troponin is a complex of three contractile regulatory proteins, troponin c, t and i, that control the calcium mediated interactions between actin and myosin in cardiac and skeletal muscles. Although the function of tnt is the same in all striated muscles, tnt originating exclusively from the myocardium cardiac tnt, molecular weight 39. Troponin t tnt conversion to ngml, ngdl, ng100ml, ng. It should be remembered that non mi causes of a raised hs troponin t may also require admission e.